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KMID : 1161420180210080769
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Journal of Medicinal Food
2018 Volume.21 No. 8 p.769 ~ p.776
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Erucamide from Radish Leaves Has an Inhibitory Effect Against Acetylcholinesterase and Prevents Memory Deficit Induced by Trimethyltin
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Kim Cho-Rong
Kim Hoi-Suk
Choi Soo-Jung
Kim Jae-Kyeom
Gim Min-Chul
Kim Youn-Jung
Shin Dong-Hoon
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Abstract
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In this study, we investigated a potent acetylcholinesterase inhibitor that was isolated from radish leaf (Raphanus sativus L.) extracts. Through sequential fractionation of radish leaf extract, the active constituent was identified as cis-13-docosenamide (erucamide). To validate the potency, erucamide derived from radish leaves was supplemented in diets and then fed to trimethyltin (TMT)-exposed mice. Specifically, mice had free access to a control diet or diets containing different concentrations of erucamide for 3 weeks, followed by an injection of TMT (2.5?mg/kg body weight). Our results showed that pretreatment of mice with erucamide (20 and 40?mg/kg body weight per day) significantly attenuated the TMT-induced learning and memory deficits that were assessed by Y-maze and passive avoidance tests. These findings suggest that radish leaves, and possibly its isolated erucamide, may have preventive effects against memory deficits related to Alzheimer's disease by modulation of cholinergic functions.
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KEYWORD
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acetylcholinesterase inhibitory constituent, Alzheimer's disease, erucamide, memory deficit, radish leaves, trimethyltin
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